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MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression [RESEARCH] 19 Aug 2013 | 07:00 pm
Memory impairment is a common feature of conditions that involve changes in inflammatory signaling in the brain, including traumatic brain injury, infection, neurodegenerative disorders, and normal ag...
Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition [RESEARCH] 19 Aug 2013 | 07:00 pm
BDNF-induced signaling is essential for the development of the central nervous system and critical for plasticity in adults. Mature BDNF signals through TrkB, while its precursor proBDNF employs p75NT...
Do different tests of episodic memory produce consistent results in human adults? [RESEARCH] 16 Aug 2013 | 07:00 pm
A number of different philosophical, theoretical, and empirical perspectives on episodic memory have led to the development of very different tests with which to assess it. Although these tests putati...
Neuronal nitric-oxide synthase deficiency impairs the long-term memory of olfactory fear learning and increases odor generalization [RESEARCH] 16 Aug 2013 | 07:00 pm
Experience-induced changes associated with odor learning are mediated by a number of signaling molecules, including nitric oxide (NO), which is predominantly synthesized by neuronal nitric oxide synth...
Requirement of the combination of mushroom body {gamma} lobe and {alpha}/{beta} lobes for the retrieval of both aversive and appetitive early memories... 16 Aug 2013 | 07:00 pm
Extensive studies of Drosophila mushroom body in formation and retrieval of olfactory memories allow us to delineate the functional logic for memory storage and retrieval. Currently, there is a questi...
Memory retrieval before or after extinction reduces recovery of fear in adolescent rats [RESEARCH] 15 Aug 2013 | 07:00 pm
Adolescent rats exhibit impaired extinction retention compared to pre-adolescent and adult rats. A single nonreinforced exposure to the conditioned stimulus (CS; a retrieval trial) given shortly befor...
Voltage-dependent intrinsic bursting in olfactory bulb Golgi cells [RESEARCH] 15 Aug 2013 | 07:00 pm
In the mammalian olfactory bulb (OB), local synaptic circuits modulate the evolving pattern of activity in mitral and tufted cells following olfactory sensory stimulation. GABAergic granule cells, the...
Sensory preconditioning in newborn rabbits: from common to distinct odor memories [BRIEF COMMUNICATIONS] 15 Aug 2013 | 07:00 pm
This study evaluated whether olfactory preconditioning is functional in newborn rabbits and based on joined or independent memory of odorants. First, after exposure to odorants A+B, the conditioning o...
Recognition errors suggest fast familiarity and slow recollection in rhesus monkeys [RESEARCH] 17 Jul 2013 | 07:00 pm
One influential model of recognition posits two underlying memory processes: recollection, which is detailed but relatively slow, and familiarity, which is quick but lacks detail. Most of the evidence...
Mechanisms contributing to the induction and storage of Pavlovian fear memories in the lateral amygdala [RESEARCH] 17 Jul 2013 | 07:00 pm
The relative contributions of plasticity in the amygdala vs. its afferent pathways to conditioned fear remain controversial. Some believe that thalamic and cortical neurons transmitting information ab...
